EXCELLING SCIENCE
to break the frontiers in predictive technologies
Triggering Cardiovascular Disease
Discovered:
- membrane wrapping of nanoparticles,
- biological consequences of the relocation of wrapped particles initiating blood coagulation
Reference:
Urbančič, I. et al. Nanoparticles Can Wrap Epithelial Cell Membranes and Relocate Them Across the Epithelial Cell Layer. Nano Lett. 18, 5294–5305 (2018).
Predicting Chronic Lung Inflammation
Discovered:
- triggering chronic inflammation by single exposure to nanoparticles,
- continuous relocation of nanoparticles among different cell types (nanomaterial cycling)
- formation of composites of nanotubes and local biomolecules (nano-quarantine).
Reference:
H. Kokot et al. Prediction of Chronic Inflammation for Inhaled Particles: The Impact of Material Cycling and Quarantining in the Lung Epithelium. Advanced materials 32, 2003913 (2020).
Find out all about our international collaborations.
References
Triggering Cardiovascular Diseases
Urbančič, I. et al.
Nanoparticles Can Wrap Epithelial Cell Membranes and Relocate Them Across the Epithelial Cell Layer. Nano Lett. 18, 5294–5305 (2018).
Koklič, T. et al.
Factor Xa Binding to Phosphatidylserine-Containing Membranes Produces an Inactive Membrane-Bound Dimer. Biophys. J. 97, 2232–2241 (2009).
Majumder, R. et al.
Phosphatidylserine-induced Factor Xa Dimerization and Binding to Factor Va Are Competing Processes in Solution. Biochemistry 52, 143–151 (2013).
Koklič, T. et al.
Ca2+ Switches the Effect of PS-containing Membranes on Factor Xa from Activating to Inhibiting: Implications for Initiation of Blood Coagulation. Biochem. J. 462, 591–601 (2014).
Koklič, T. et al.
Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces. Biochem. J. 467, 37–46 (2015).
Predicting Lung Inflammation
Kokot, H. et al.
Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium. Advanced Materials 32, 2003913 (2020).
Danielsen, P. H. et al.
Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice. Toxicol. Appl. Pharmacol. 386, 114830 (2020).
Triggering Neuro-Degeneration
Sebastijanović, A. et al.
Neurotoxicology in review (2023).