To make advanced sensory device, science needs to discover new ways to see the early molecular events involved in the evolution of diseases (which we called Adverse Outcome Pathways or AOPs).

 

At Laboratory of Biophysics @ Jožef Stefan Institute, from which Infinite is spun out, multi-channel super-resolution microscopy such as STED is used to track the response of tissue-on-chip.  Material is co-localized with molecular changes and connect with further events in the associated Adverse Outcome Pathways. Some of the events have already been associated to cardiovascular and chronic diseases scientifically grounding the technology of our sensory devices.

 

nano on neurons
chronic cycle

In the example above, neurons are exposed to TiO2 nanotubes (red), which are passivized on the neuronal surface. Large bio-nano agglomerates can be seen along axons and body of a neuron, built from nanomaterial (red) and membranes (gray).

Awesome SyGlass technology is used to present this 3D image.

In the paper, recently published by Laboratory of Biophysics @ Jožef Stefan Institute, pasivation of nanomaterial has been clearly associated with chronic inflammation.

Manucript has been deposited on BioRxiv.